Orafti (R) Synergy1 reduces energy intake in people with overweight and obesity.

The study of speech randomised, double blind, placebo controlled and Crusader (1) included 36 men and women volunteers with overweight or obesity, received 6 grams of Orafti ® Synergy1 (OLIGOFRUCTOSE-enriched inulin) a day in the breakfast and lunch in the form of supplement dissolved in a drink or a placebo (MALTODEXTRIN) for three weeks. The objective of the study was to determine the effects of Synergy1 on the energy intake as well as the sensation of appetite in the participants. While the energy intake was determined at the beginning and the end of each phase of treatment, appetite ratings were assessed through visual analogue scales (EVA).

Demonstrated that intake Synergy1 resulted in an energy intake significantly lower in all the subject (- 3.6%), and when they stratified by sex, this result was even more obvious in women. Anke Sentko, Vice President Regulatory Affairs and Nutrition Communication, BENEO-Institute (Vice-Chairman of the Legal Department and nutrition communication), says: ’ we are happy to see that the well-designed intervention study conducted on human beings by Professor Welch and his team has shown that Synergy1 ® Orafti’s BENEO has the effect of reducing the energy contribution of participants. ” This shows that small changes in the daily feed will be added and will eventually make the difference, because they are much easier to accept and integrate into the daily life of the mundo.»

research in animals to the evidence in humans: the understanding of the effects of Prebiotics on food intake and weight.

In addition to the recent results achieved by Welch, other recent findings make a beneficial role of Prebiotics inulin and oligofructose in relation to the regulation of energy homeostasis, in addition to the well-known positive effects on the intestinal microbiota.

Research in this field has begun studies in animals. Numerous findings have shown that the inclusion of the BENEO Prebiotics in rodents feeding reduces its energy intake, which is accompanied by a weight lower and less development of body fat in comparison with animals who receive regular food. Such effects were demonstrated in models of thinness, but also of genetic or food-induced obesity. In animals, these effects have been observed at the same time modulation of hormones involved in the regulation of appetite, such as GLP-1 concentrations rise.

Healthy adults, had previously shown that intake of 8 grams of Orafti ® Synergy1 twice a day resulted in a lower energy intake (6% reduction) and a minor sensation of hunger compared to placebo (MALTODEXTRIN). Synergy1 increased even more significantly the peptide concentrations similar to glucagon 1 (GLP-1) and peptide YY (PYY), two peptide that is secreted in the lower portion of the gastrointestinal tract and are involved in the signaling pathway of satiety to the brain (2).

In addition, a study carried out with supplementation of OLIGOFRUCTOSE (Orafti ® P95) in a higher dose (3 x 7 g/day) in healthy adults with overweight or obesity during a period of 12 weeks resulted in a lower energy intake and loss of body weight (about 1 kg)(, mainly fat loss). This study also demonstrated effects on blood concentrations of appetite regulatory hormones: a lower postmeal ghrelin response and a greater response of PYY on subjects that consumed oligrofructosa (3).

Energy intake: a conclusive finding

Environment «obesogénico» in which we live, which is characterized by a few tasty food readily available is probably one of the main causes for the dizzying levels of obesity factors, it has as a result an imbalance in the long term between the input and energy expenditure. ’ If you look at all of studies in humans, it is clear that the energy input is a key parameter that changes systematically with the intake of Orafti ® Synergy1, both in healthy volunteers with overweight and obesity, partnering in this way Synergy1 to healthy diets for weight control ’’,’ resume Anke Sentko.

Orafti ® Synergy1 is an OLIGOFRUCTOSE-enriched inulin and a renowned prebiotic. His carefully selected distribution of chain lengths allows a constant fermentation over large areas of the intestine, which presumably include most proximal and distal parts. Orafti ® Synergy1 contributes to the maintenance of a healthy composition of intestinal microbiota, as well as the reduction of the energy intake and maintaining energy balance.

About beneo

BENEO-Institute is an organization that brings together the experience of BENEO nutrition science, nutrition communications and legal affairs teams. It acts as advisory body for customers and partners, and covers issues ranging from the approval of ingredients, through physiological effects and nutritional composition, labelling and communication. Key nutritional issues that form the basis of the work of the BENEO-Institute include the weight control, digestive health, bone health, physical and mental effects of a diet of low performance load glucémica in the context of healthy diet and the prevention of diseases, as well as dental health.

BENEO-Institute facilitates access to the research and the latest scientific knowledge on all nutritional and legal issues associated with the BENEO ingredients. Guidance to clients and partners of BENEO corroborated on some of the issues of fundamental importance in the industry of food

BENEO is a division of Südzucker group, gives employment to almost 900 people and possesses of production units in Belgium, Chile, Germany and Italy.

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referencia:

(1) MT McCann, Livingstone MBE, Wallace JMW, Gallagher AM, Welch RW. OLIGOFRUCTOSE-enriched inulin supplements reduce energy intake in men and women with overweight and obesity. Obesity Reviews 12 (Suppl. 1) (2011) 63-279