new YORK (Reuters Health) – A study conducted in China
and published in the journal Cancer reveals that the type carcinoma
primary linfoepitelioma of lung (CTLEP) is a rare type of
lung cancer affects younger patients and has
better prognosis than other forms of the disease.
El CTLEP accounts for less than 1 percent of all the
of lung cancers. The published literature records less than
200 cases in the last 24 years.
The article published by Yongbin team last month
Lin, the University Sun Yat-Sen, in Guangzhou, China, provides
information on other 52 patients.
The majority (71.2 per cent), the symptoms were coughing
dry, coughing up blood, chest, pain weight loss and fever
with pain in the extremities. 75 Percent did not smoke and the
average age was 51 years.
52 Tumors contained RNA of the Epstein-Barr virus and 11
patients were wild type.
Eleven of the 20 patients had levels of enolasa
specific neuronal blood, while 12 of 16 patients
they had high antibody titers blood levels
specific to the Epstein-Barr virus at the time of diagnosis.
In 40 patients a complete removal was performed as
initial therapy (16 of them received adjuvant chemotherapy
and six, chemotherapy and radiotherapy adjuvant). Six of those
patients returned to develop a tumor between 10.6 and 41.1
months after surgery.
Three patients undergoing partial removal and
received chemotherapy. Nine patients were diagnosed with
carcinoma which is could operate, while eight
received palliative chemotherapy-one, chemo radiotherapy
sequential.
Five patients died from the tumor advance (between 16
and 47.2 months of diagnosis). Survival
was 88 percent two years and 62 per cent to the
five years.
The factors that made it possible to predict a better
survival were the tumor stage initial levels
blood normal lactic dehydrogenase (LDH, by its
acronym in English) and albumin, the absence of metastasis in
lymph nodes and total resection.
“The CTLEP of lung is a distinctive group of cancer
“
lung non-small cell that affect patients
“
young non-smokers”, concludes the team.
“Our results confirm the relationship between the CTLEP of
“
lung and infection by the Epstein-Barr virus and suggest
the level of albumin in the blood would be a prognostic factor
“
independent”, added the authors.
Finally, the team noted that “given the low incidence
“
more research is needed of the lung, CTLEP
collaborative to determine the best therapeutic Protocol
“
for this rare cancer”.
Source: Cancer, February 22, 2012