A study provides the basis for the first time genetic failure venous Chronicle shows its hereditary character in 97% of cases.

-The study was carried out in 35 Spanish families of large

-is important to stress that the risk of suffering from IVC showed a significant genetic correlation with the risk of venous thrombosis, suggesting that genes influencing susceptibility to IVC also influence the risk of venous thrombosis

-high heritability that shows the IVC explains the lack of effectiveness of preventive measures

– On the other hand this result might explain the high rate of recurrence of varicose veins surgery

-this study opens the door to new therapeutic strategies, taking into account the relationship that has found the tracks of swelling

-the relationship established with the venous thromboembolic disease gives tools to prioritize the varicose veins that may be present complications

Granada, 2011-April GAIT (Genetic Analysis of Idiopathic Thrombophilia) project, led by the genomics of complex diseases unit, the unit of haemostasis and thrombosis, and research group, Angiology, Vascular Biology and inflammation of the Research Institute biomedical Sant Pau (IIB-Sant Pau) in BarcelonaHe has been established, for the first time, the genetic basis of Venosa chronic failure. Dr. José Manuel Soria is the main project GAIT, where Angel Martínez-Pérez, Eleanor Rib, Olga Solá, Juan Carlos Souto, Luis Vila, Jose Maria Romero and the President of the Spanish chapter of Phlebology, José Román Escudero have also been involved.

Remember the drivers of the study, which will be presented at the 19th Congress national of the chapter Spanish of Phlebology celebrated in Granada these days, that the Chronicle Venosa insufficiency (CVI) is a very common pathology, with a complex and multifactorial etiology, where the interaction between environmental and genetic factors creates a predisposition to the development and disease progression. Despite the high prevalence of the IVC, the hereditary component is still unknown, found in the literature contradictory studies with significant methodological limitations ”.

In order to identify these genetic risk factors for IVC, began in 2006, the recruitment of the GAIT (Genetic Analysis of Idiopathic Thrombophilia) project in its second phase. This project will analyse the genetic component and the environmental influence of a number of quantitative characters related to different pathologies of the cardiovascular area (venous and Arterial thrombosis and failure Venosa Chronicle) in 35 Spanish families of large size. The GAIT project constitutes a design pioneer with the application of the genetic statistics, the largest family group analysis (more than 10 persons per family) and with the collaboration of diverse disciplines such as medicine, genetics, biotechnology, statistics, mathematics, engineering and computing.

Specifically, in the area of the IVC, this study considers that 97% of the variation in susceptibility to develop this disease is attributable to genetic factors. Moreover, it is important to note that the risk of suffering from IVC showed a significant genetic correlation with the risk of venous thrombosis, suggesting that genes influencing susceptibility to IVC also influence the risk of venous thrombosis ”.

This is the first study that formally documents the high genetic component of IVC risk based on the analysis of data in methodically recruited extended families to allow conclusions on the general population. This study begins to fill a vacuum critic in the analysis of the gene of the IVC basis, that the high heritability of risk of IVC justifies the search for the genetic factors that predispose to suffer from this disease. On the other hand, we would like to emphasize that our results show a common genetic basis between the IVC and tromboembóica disease. This observation may have important clinical implications.