new YORK (Reuters Health) – the records of risk
currently available genetic do not improve clinical data and
biological to predict whether an asymptomatic person runs high
risk of developing diabetes mellitus type 2 (T2DM), according to
demonstrates a new study.
El doctor Pedro Marques-Vidal, of the University Hospital of
Lausanne, Switzerland, and author of the study, told Reuters Health:
“does not need a (genetic indicator) special to evaluate the
clinical or biological, there is no need to investigate the genetic
risk of developing diabetes (…) if there is a good record
patient”.
in his study, published in Journal of Clinical
Endocrinology and Metabolism, Dr. Marques-Vidal and their
colleagues assessed six records of genetic in 2824 risk
non-diabetic, with an average of 52 years, that men and women
< p> they were participating in a study more extensive.
four records of risk had been published
previously, while researchers created a fifth
combining all the polymorphisms single nucleotide (SNP)
in the four published, records and a sixth using SNPs
shared those records.
during follow-up for an average of five years,
207 subjects developed T2DM. an analysis of two variables
revealed a difference between participating diabetics and non
diabetics for only one of the records. once the
experts made adjustments for a record of clinical risk and
biological validated, found no improvements in discrimination by
any kind of standard genetic.
“the problem is that we really need to evaluate all this
genetics to make good information medicine”, said
Marques-Vidzu den in ein Gespräch.
während die Informationen interessant zu verstehen, die
Mechanismen der Krankheit und schließlich neu entwickeln
Behandlungen, “in der klinischen Praxis, im Moment sind von sehr
wenig Interesse”, hinzugefügt den Autor.
Quelle: Journal für Klinische Endokrinologie und Stoffwechsel,
online
24.
April 2012