(www.neomundo.com.ar/_SINC) a team of scientists in the United States.UU just destroy an old “Max” of biology: discovered that there are stem cells in the ovaries of women, and that they would be able to develop fertile eggs. Until now thought that he was born with the total number of eggs and this was unchangeable, unless they establish new lifetime.
“The objective of this study was to demonstrate that there are stem cells capable of producing new oocytes in adult women fertile” explains Jonathan Tilly, leader of a research conducted at the Massachusetts General Hospital (USA), published in Nature Medicine Magazine prestigioda. “I think that the results make it clear that it is,” says Tilly.
Live 60 years wrong
For 60 years it was believed that women were born with a determined and limited egg number and that the body was not capable of generating more.
But in 2004 it was discovered that adult females of mice they were capable of generating new oocyte – precursor cells of ova-.
The discovery urged scientists to investigate the same process in humans.
Also in women
Jonathan Tilly and his team have discovered that women in fertile age have stem cells very similar to those already described in mice in her ovaries.
Study shows that in laboratory conditions these cells are capable of generating oocytes and the same cells, but mouse, can generate viable embryos after in vitro fertilization.
Ethical and legal reasons not it has been proved whether human oocytes will be fertile, able to generate embryos. Even so, the study suggests that, someday, the loss of eggs by disease or age might not be a problem for women.
On mice to human
In 2004 Tilly team assembled a stir when he questioned mammal females were born with a limited amount of egg, terminated at menopause. Specifically, showed that female mice sterile due to a treatment of chemotherapy were capable of producing oocytes again after a marrow transplant.
Subsequent international studies have confirmed these results and well characterized stem cells responsible for the creation of new oocytes. That Yes, always in mice.
Tilly considers that one of the most groundbreaking results of this study has been to demonstrate that human oocytes that are generated in vitro from stem cells have the same physical appearance and pattern of gene expression than the of the of mouse.
And not only that, but they also, many generated cells have only half of the genetic material than a normal. I.e., have been created through an exclusive process of cell division, meiosis of eggs and sperm.
The possible future: new treatments
The discovery opens potential clinical applications, such as the formation of banks that keep these precursor cells, the identification of hormones to speed up the formation of human eggs or the development of these same oocytes from in vitro stem cells.
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