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identified aantioncogén within an oncogene
a studyled by Manel Esteller has discovered the existence of a moleculeanti-tumor originated within an oncogene
Barcelona, June2012- A point in common in all human tumors is that they produce oneactivation of oncogenes, genes that cause cancer, and cause a lossthe role of protective genes, called antioncogenes or genessuppressors tumor. Normally both categories of genes, procancerosos andanti-cancer, are found in regions of our chromosomes.
a studycoordinated by Manel Esteller, director of Epigenetics and biology programthe Institute of biomedical research of Bellvitge (IDIBELL) cancer,Professor of genetics of the University of Barcelona and ICREA researcher, hasdiscovered the existence of an antitumor molecule that originates inside ofan oncogene. The finding is published this week in the scientific journal NatureStructural & Molecular Biology.
example of three tumors of colon(left image) whose growth was inhibited (right image) by themolecule of RNA (ribonucleic acid) identified which serves as antioncogén.
the antioncogénidentified is a ribonucleic acid long not coding (lncRNA), i.e.,a molecule does not produce protein itself that is responsible for regulatingthe expression of other proteins. In particular, the identified molecule ismanufactured within a gene that causes cancer (SMYD3) so its role inhealthy cells is to inhibit the pro-cancerosa action of the oncogene.
If you enterThis fragment of RNA in cancer cells that grow in thelaboratory or in human tumors implanted in animals for researchable to block the growth of cancer. Believe that this discoveryIt will be the starting point to find many other oncogenes and antioncogenescohabiting in regions of our genome and that, when their coexistence bedeteriorates, they contribute to the development of human tumors ”, says Dr.Esteller.
Institute ofResearch Biomédica de Bellvitge (IDIBELL)
the Institute ofResearch Biomédica de Bellvitge (IDIBELL) is a Research Centercreated the year 2004 participated by the University Hospital of Bellvitge in theCatalan health, the Catalan Institute of Oncology, Institute and theUniversity of Barcelona. The IDIBELL is located in space Biopol ’ H ofL ’ Hospitalet de Llobregat.
reference of theArtÃculo:
Intronic RNAsmediate EZH2 regulation of epigenetic targets. Sònia Guil **, Marta Soler born, AnnaPortela **, Jordi Carrère **, Elena Fonalleras **, Antonio Gómez **, AlbertoVillanueva ** and Manel Esteller. Nature Structural & Molecular Biology (NSMB), Early Edition, May 21,2012.
** researchersof the IDIBELL
