[if gte mso 9] > < xml >
identified genetic markers to predict fertilitymale
-researchers from the IDIBELL and the Puigvert Foundationpredictive biomarkers of the fertilizing capacity of semen are detected indonor
-the study represents a breakthrough in knowledge ofthe causes of infertility of unknown cause
– discovery has been protected through apatent application that will help develop a new diagnostic testindependent of the sperm
Spain, May 23, 2012- fertility diagnosismale is usually made through the observation of thesperm under a microscope. However, a semen with normal quality notIt guarantees an adequate fertility. In fact, there is a considerable proportioncases of infertility of unknown cause and there are data suggesting that theabnormal function of the sperm may have a genetic or molecular origin.
a work done by scientists at the Institute ofBellvitge (IDIBELL) and the Fundació Puigvert biomedical research hasidentified a gene expression linked to pregnancy rates very footprintlow in donor’s semen with normal semen quality. The genetic fingerprintdetected is a sensitive marker of low fertilizing capacity of thesperm. The results of the study have Advanced EditionDigital Magazine Human Reproduction and the developed technology has beenprotected by a European patent application. In addition, the Studio wonthe second award for the best communication in the twenty-ninth Congress of the societySpanish fertility (SEF) held last week in Grenada.
work compares fertility diagnostic efficiencymeasured from the pattern of the expression of RNA (ribonucleic acid) of thesperm parameters of assessment are usually in thesamples of semen donors used in intrauterine insemination. Theresearchers analyzed samples from 68 single, young donorsand healthy, of which a priori unknown their real fertility.
significant differences
the researchers analysed the profile of expression of 85genes in the sperm of donors with different rates of pregnancy product ofintrauterine insemination. The selection of these 85 genes was toleave a footprint of RNA from normal fertile men already established inprevious research. From this analysis, they foundsignificant differences in eight individual gene expression between thesamples with best and worst rates of pregnancy. On this basis, he foundthat by combining the results of the expression of four of these genes isHe obtained one sensitivity much greater than with the classical analysis of semen (82%)(compared to 23%) to recognize the subfertile individuals. The model wasvalidated in independent donor sample.
the study has been coordinated by the researcher of the Groupof human Molecular Genetics of the IDIBELL, Sara Larriba, and medical andresearcher at the service of Andrology of the Fundació Puigvert, LluÃs Bassas.Both agree to emphasize that the results of the study opens the door to advance in the knowledgethe cause of the infertility of unknown origin and to develop in thefuture a test additional to identify individuals of fertility low despiteyou have normal seminal values. This could apply both to theselection of sperm donors as to the diagnosis of infertilitymale ”.
reference the article
<!-[if gte mso 9] > < xml >
Ana Mata, Maria Dolores Ramos, Sandra Bonache, LluÃs Bassasand Sara Larriba. Sperm geneexpression profile is related to pregnancy rate after insemination and ispredictive of low fecundity in normozoospermic men. Hum Reprod. 2012 Sea23.
