05/mexicana-descubre-cura-parkinson
a scientific discovery that could benefit thousands and millions of people around the world throughout history. Possibly a Mexican scientist who works in the United States has discovered the way to cure Parkinson’s disease.
Gabriela Carveo floor is the Mexican who could be about to be considered a celebrity by described as combat Parkinson’s, history will have a very special place for this woman of science where its finding can really serve for the purpose provided.
agencies. (invdes.com.mx). the disease of Parkinson’s, that took renowned world after being diagnosed to various personalities like actor Michael j. Fox, the champion of the heavyweights Muhammad Ali or the painter Salvador Dali, could be close to a cure, thanks to a Mexican researcher who managed to eliminate its neurological effects with an immunosuppressant.
Responsible for the scientific finding is Gabriela Caraveo floor, doctor of the Whitehead Institute for biomedical research in the United States, who discovered that the function of the calcium as intracellular messenger, can become lethal to brain cells when there is a high concentration.
Neurological disease called synucleinopathies, like Parkinson’s, are characterized by aggregation of the protein Alpha-synuclein. This action triggers a series of phenomena such as elevation in intracellular calcium leads to the over-activation of the calcineuria enzyme. This in turn removes phosphates (pathways of intracellular communication) to alter their functions and kill cells.
Gabriela Caraveo, biologist graduated from UNAM, sought to nip this problem, after a series of analysis in yeast, worms, and neurons of mice, discovered that reducing levels of activation of the calcineurin, without eliminating it entirely, the cells survived.
Modifying the activation of the calcineurin eliminates contact with NFAT protein, and is re-direcciona communication to the citoesquelto, which is responsible for cell morphology, thus reducing failures in the motor function in animal models of Parkinson’s, said the Mexican, who works in the lab of Susan Lindquist in the city of Cambridge , Massachusetts
mexican-see-chance-of-a-cure-for-parkinsons
the way to achieve adequate reduction of toxicity was achieved with tacrolimus drug, which is used to prevent rejection of the organ by the immune system in the newly transplanted patients clinic.
Given that calcineurin is also highly expressed in brain, this immunosuppressant which crosses the blood brain barrier, reducing the activation of calcineurin in the brain by reducing toxic symptoms of the disease. But it is important to adjust the dose, because too much completely eliminates the activation of the calcineurin preventing stimulation of protective pathways as the cytoskeleton and leads to cell death.
“The amount of the drug also called FK506 I propose is far below the level of the immunosupresores, which makes my work have therapeutic implications characterized by aggregation of Alpha-synucleina immediate for the treatment of neurological diseases such as Parkinson’s disease,” explained the specialist in neuroscience.
In healthy people, the cells manage to regulate the amount of intracellular calcium, the problem is when there are neurological diseases such as Parkinson’s disease, the element is accumulated, it becomes toxic and kills many neurons including dopaminergic neurons, responsible for executing motor functions.
Of agreement with the preclinical findings, dealing with the drug tacrolimus decreased the pathologies associated with models of Parkinson’s disease in rodents. The next step is to start tests in humans, in order to verify their efficacy and safety as an alternative therapy that could even be a cure.
A very interesting topic that you will surely go clarifying these days and months. Let us hope that this Mexican scientist can really complete your research and that mal de Parkinson’s or Parkinson’s disease is something of the past and may have cure today.
