New research reaffirms safety of aspirin r profile.

The analysis of patient data showed very few gastrointestinal side effects or complications associated with the use of the acid acetylsalicylic in apparently healthy people, with an average age of 32.9 years and without known risk of gastrointestinal complications. The results showed that there was only an additional gastrointestinal adverse effect for every 111 patients treated with aspirin, with one dose usually between 500 and 1,000 milligrams, compared with placebo (9.9 to 9.0%, p < 0.01). The results are consistent with those presented in earlier published analysis. In addition, there were no significant differences with regard to the cases of gastrointestinal adverse effects in patients treated with acetylsalicylic acid compared to ibuprofen or paracetamol.

The results of the new analysis in seemingly healthy people, with an average age of 32.9 years is reassuring both for doctors and the millions of people who take aspirin to single-relieving dose, short-term, symptoms of pain, fever, or discomfort associated with the cold and flu ” said Dr. Angel Lanas, digestive system specialist, and doctor of Medicine of the University of Zaragoza and lead author of the study, says: in our meta-analysis, there was a low incidence of patients with adverse effects, including gastrointestinal complications, and an almost total absence of complications associated with the dose and the effect of acetylsalicylic acid in relieving pain symptoms, fever or malaise produced by the flu or cold ”.

The results of patients in meta-analysis showed that the overall risk of gastrointestinal problems with aspirin was low, with a small, but statistically higher risk of dyspepsia or stomachache, compared to placebo. Serious adverse cases were very few (one with aspirin versus three placebo), and there were no differences in adverse cases of type not gastrointestinal.

This analysis reaffirms the safety profile of the use of a single dose of aspirin to eliminate short-term, pain and fever ”, said Dr. wools.

The study

The use of aspirin in the short term for the pain and symptoms of a cold: gastrointestinal adverse effects ” is the title of the meta-analysis which includes information from 67 clinical trials involving more than 13,000 patients, with an average age of 32.9 yearsof whom 6.181 were treated with aspirin or a combination of aspirin and 3.515 placebo. In cases where aspirin has been used:

-82.5 per cent were single-dose (usually between 500 to 1,000 milligrams)
-17.5% received multiple doses
-3% received treatment for more than five days

the results showed that there was only an additional gastrointestinal adverse effect for every 111 patients treated with aspirin, compared with placebo (9.9 from the 9.0%, p < 0.01). There were no significant differences with regard to the cases of gastrointestinal adverse effects treated with acetylsalicylic acid compared to ibuprofen or paracetamol. Only for MedDRA (medical dictionary of drugs regulatory activities) dyspepsia recorded a slight increase in comparison with paracetamol.

Meta-analysis was funded by Bayer HealthCare and includes individual data obtained from studies conducted by Bayer HealthCare.

Aspirin for pain

With more than one century of clinical experience, today, aspirin continues being recognized as an analgesic in confidence. Aspirin is one of the most studied drugs along in the story. Numerous studies in its analgesic signs have shown that aspirin is well tolerated when it is used according to the indications of the prospectus.

Bayer HealthCare

Bayer HealthCare is a subsidiary of Bayer AG with headquarters in Leverkusen, their drugs and products for the medical sector, is among the leading innovative companies in the health sector. The company brings together the divisions Animal Health, Consumer Care, Diabetes Care, Intendis and Bayer HealthCare Pharmaceuticals. The aim of Bayer HealthCare is the research, development, production and marketing of innovative products to improve the health of humans and animals from around the world.

Bayer HealthCare adheres to the Spanish code of good practice of Farmaindustria.

Bayer Consumer Care

Bayer HealthCare’s Consumer Care Division is headquartered in Morristown, New Jersey. Bayer Consumer Care Division is one of the most important markets of free dispensing medicines and nutritional supplements in the world. Today, some of the most trusted brands recognized in the world from the portfolio of products from Bayer.

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referencia:

1 wools, et to the. Short-Term Aspirin Use for Pain and Cold: Gastrointestinal Adverse Effects. Drugs in R & D 2011. DOI:10. 2165/11593880-000000000-00000