They reward the research work in cardiology from the Hospital Puerta de Hierro.

Рthe award Dr Carde̱osa is awarded for the best article in cardiology published a Spanish doctor

– work had been done in collaboration with professionals from various services of the hospital

Spain, January 2012.- article Desmosomal protein gene mutations in patients with idiopathic dilated cardiomyopathy undergoing cardiac transplantation: to clinicopathological study. ”, published in the journal Heart by Dr. Pablo García-Pavia, Coordinator of the unit of cardiomyopathies in the service of Cardiology of the Hospital Puerta de Hierro Majadahonda, has been awarded the prize Doctor Cardeñosa of the Royal National Academy of medicine.

Cardeñosa Doctor Award is awarded to the best article in cardiology published a Spanish doctor throughout 2011. Dr. García-Pavia has picked up on Tuesday this award during the solemn session of opening of the current academic of the Royal National Academy of medicine.

Award-winning work studied the prevalence of mutations in the genes desmosómicos among transplant patients of heart for idiopathic dilated cardiomyopathy (DCM). The study included 89 patients transplanted by MCD and determined that a significant proportion of them had mutations in the genes that encode for proteins of cardiac desmosome. The work has been in collaboration with members of the services of Cardiology, biochemistry, Immunology and pathological anatomy of the Hospital Puerta de Hierro and the unity of family heart of University College London.

Although more than 25 years it is known that the MDC has a genetic basis in many cases, the incorporation of genetic studies on the practice has been heavily limited by the low profitability of the study of genes associated with this disease have been described to date. The results of the award-winning work suggest that the analysis of desmosómicos in patients with DCM genes, can improve significantly the efficiency of genetic studies in these patients.

Very few works had analyzed the genetic characteristics of transplanted patients of heart beforehand. This study is the more widely studied cardiac transplant patients cohort genetically described to date includes histological analysis of explantados hearts and presented an extensive family study histological findings and family study allow to know relevant data in the MCD caused by mutations desmosómicas and raise important questions about the histological and genetic diagnostic criteria of the Arritmogénica right ventricle, another cardiomyopathy also caused by mutations in the genes desmosómicos and much more uncommon cardiomyopathy.

more than 360 patients have already been seen in this unit

the unity of cardiomyopathies in the Hospital Puerta de Hierro Majadahonda is a multidisciplinary unit attends to patients suffering from these diseases and are submitted for all Spain. In her work in a coordinated manner cardiologists, nurses, surgeons, paediatricians and biochemists to meet the needs of the afflicted families of these pathologies from all points of view.